Plasmid Incompatibility: Should You Care?

#59 — Have you heard of plasmid incompatibility? Should you be worried about it? Listen to this episode of Mentors At Your Benchside to discover exactly what plasmid incompatibility is, how it can affect your research and what you can do to overcome it.

Read the full article for helpful figures, [1] read the review with a list of incompatibility groupings, [2] check out the detailed review by Novick et al. for details on the categories of incompatibility, [3] and access the review on incompatibility mutations. [4]

1. Understanding Plasmid Incompatibility.  Available at:
2. Novick RP, et al. (1976) Uniform nomenclature for bacterial plasmids: a proposal. Bacteriol Rev. 40(1):168-89. Available at:
3. Carattoli A. (2009). Resistance Plasmid Families in Enterobacteriaceae. Antimicrob Agents Chemother. 53(6):2227–38. Available at:
4. Camps M. 2010. Modulation of ColE1-like Plasmid Replication for Recombinant Gene Expression. Recent Pat DNA Gene Seq. 4(1):58–73. Available at:

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Dr Laura Grassie
Dr Laura Grassie
Content Creation Manager, Bitesize Bio
Plasmid Incompatibility: Should You Care?